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Caution should be used in the following populations, as dose adjustments may be required. The dose must be pharmacology katzung pdf free download in those with poor kidney function.

No controlled data in human pregnancy are available. Birth defects have been associated with use of lisinopril in any trimester. However, there have been reports of death and increased toxicities to the fetus and newly born child with the use of lisinopril in the second and third trimesters. The label states, “When pregnancy is detected, discontinue Zestril as soon as possible. The manufacturer recommends mothers should not breastfeed while taking this medication because of the lack of safety data that currently exists. The inhibition of this system causes an overall decrease in blood pressure.